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[114] not only demonstrated that mitochondrial fission is impaired in T2DM db/db hearts, but also that the proposed mechanism of reduced Mfn2 expression may have been a consequence of reduced expression and binding of PPAR to the Mfn2 promoter, thus providing more evidence of a link between lipid metabolism and impaired mitochondrial dynamics in DbCM

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Involvement of extracellular superoxide dismutase and NO

Dietary polyphenols have been reported to have various biological activities including polyphenols, which have immunomodulatory, antioxidant, anti-inflammatory, anti-allergic antimicrobial, ant- mutagenic, and detoxification activities (152)

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