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doi: 10.1016/j.bbadis.2021.166204 76 FarrsMRomnRCampsMMiretJMartnezPujolXet al

& Segel, S., 2005

Nitric Oxide Biol Chem 17:115121

5.2 Targeting ammonia death to promote tumor immunotherapy 5.2.1 Ammonia death and adoptive T cell therapy The concept of ammonia death in effector T cells, recently proposed by Professor Huang Bos team, offers valuable insights for improving T-cell-based cancer immunotherapy by enhancing the survival of Teff cells ( CAR-T immunotherapy, one of the most innovative approaches in adoptive cell therapy, has shown considerable success in treating hematological malignancies (167, 168)