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In the penile microenvironment, preclinically demonstrated systemic inflammatory signals induce a series of structural and functional abnormalities that may lead to ED, including endothelial cell dysfunction, phenotypic transformation and apoptosis of cavernous smooth muscle cells (CSMCs), and inflammatory damage to penile nerves (204)

more commonly, however, the nodule functions enough to suppress the remainder of the gland, but not enough to produce clinical hyperthyroidism (8)

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Skalen K, Gustafsson M, Rydberg EK, Hulten LM, Wiklund O, Innerarity TL, Boren J