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At a site of inflammation, oxidative stress is mediated by reactive oxygen species (ROS) generated primarily by activated leukocytes (neutrophils, macrophages, eosinophils)

Transport dynamics in a glutamate transporter homologue

Many metabolic pathways associated with mitochondria, such as the mitochondrial tricarboxylic acid cycle and electron transport chain, have the capability to generate ROS

Macrophage-mediated inflammation in skin wound healing

During oxidative stress, the oxidized DJ-1 may translocate to the outer membrane of mitochondria and it has been shown to prevent MPP + induced cell death, the mechanism of which remains unclear [12]

doi: 10.1126/science.aam9305 Summary Keywords dendritic cells, glutamine, macrophages, glutamine synthetase, glutamate Citation Schoeppe R, Babl N, Decking S-M, Schnhammer G, Siegmund A, Bruss C, Dettmer K, Oefner PJ, Frick L, Weigert A, Jantsch J, Herr W, Rehli M, Renner K and Kreutz M (2023) Glutamine synthetase expression rescues human dendritic cell survival in a glutamine-deprived environment