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Poster Session II - ACUTE ISCHEMIC STROKE MANAGEMENT 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.06 - IMAGING - Hyperacute P668 - ESOC25-2412 DOES CEREBRAL SMALL VESSEL DISEASE COMPROMISE LEPTOMENINGEAL COLLATERAL FLOW IN LARGE-VESSEL OCCLUSION ISCHEMIC STROKE

Constant, discriminative, and almost non-overlapping relative shifts in mean TW CCS N2, meas were obtained for demethylation ( 6.5 2.1 2 ), oxygenation (hydroxylation + 3.8 1.4 2 , N-oxidation + 3.4 3.3 2 ), acetylation (+ 13.5 1.9 2 ), sulfation (+ 17.9 4.4 2 ), glucuronidation (N-linked: + 41.7 7.5 2 , O-linked: + 38.1 8.9 2 ), and glutathione conjugation (+ 49.2 13.2 2 )

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It is a very potent serum that will produce satisfactory results

Cagrilintide's fatty-acid acylation extends its half-life to roughly 160 hours, so circulating levels rise gradually over the first weeks of dosing rather than peaking immediately (Enebo et al., 2021)

Protein bands were visualized using a Tanon 5200 Imaging System (Tanon, Shanghai, China)