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Toxicological Sciences: An Official Journal of the Society of Toxicology, 145 (1), 3747

Schedule: Daily injections for 812 weeks (optional extension up to 16 weeks ), followed by a 24 week break for protocol cycling

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Concurrently, downregulation of STAMBP and NEP may impair protein clearance mechanisms, exacerbating proteotoxic stress and -amyloid (A) deposition [52], ultimately triggering neuronal apoptosis, which aligns with our previous observation of reduced MAP2-positive neurons

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The TME of pancreatic cancer is highly disordered, and in stark contrast to the more organized and clearly defined tumor masses found in some other cancers, the scattered cancer cell nests are surrounded by a rich stroma interspersed with CAFs and immune cells, which is a hallmark of pancreatic cancer [11]