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Moreover, various specialized pro-resolving mediators (SPMs) produced from omega-3 PUFAs help in moderating undue neuroinflammatory responses and inflammatory pain, facilitating communication between glial cells and neurons

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However, once pre-cancerous lesions are established, high circulating folate concentrations, particularly from excessive folic acid supplementation, may accelerate the growth of rapidly dividing cells

Hence, the presence of iron overload in the FF of infertile patients with EMs can promote NCOA4 expression within granulosa cells, leading to active ferritinophagy, which further contributes to the development of ferroptosis by enhancing lipid peroxidation in granulosa cells

Mitochondria and ferroptosis in the testis Mitochondria are the powerhouses and the sources of ROS production in eukaryotic cells [50]