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This paper draws attention to the extracellular matrix composition of demyelinated lesions as an important determinant of remyelination efficiency and how remyelination can be improved by pharmacological manipulation of the lesion extracellular matrix

References NHS: British Skin Foundation: PubMed (UK access): NICE (National Institute for Health and Care Excellence):

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The cellular concentration of GSH, therefore, is regulated by a complex process of precursor amino acid transport across cell membranes, intracellular synthesizing enzymes, feedback regulation, and intracellular GSH complexing via conjugation of GSH with a variety of electrophilic compounds through GSH transferase reactions

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These studies found structural and functional defects in the 26S and 20S proteasomes, with a significant loss of the alpha subunit of the 20S proteasome, a loss of its enzymatic activity, and a significant decrease in the regulatory function of the 19S particles [128, 134, 135]