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Both reports confirm the expert opinion recently reported by the author where lactate (Warburg effect) increases the steady-state ROS condition in cancer cells 4 and the published work that antioxidants are the guardians and gatekeepers against oxidative stress-induced hepatocarcinogenesis 24

ARA-290 does not trigger that pathway

Neurochem Res 30(3):403410 Porciuncula LO, Rocha JB, Boeck CR, Vendite D, Souza DO (2001) Ebselen prevents excitotoxicity provoked by glutamate in rat cerebellar granule neurons

For example, ROS produced by macrophages can induce the generation of Tregs [238], while mice lacking neutrophil cytosolic factor 1, even with low ROS levels, have more responsive Tregs than wild-type mice [168]

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Thermal profiling was performed using a Veriti Thermal Cycler (Bio-Rad, Bio-Rad Laboratories, USA) across an 8-point temperature gradient (37.0, 41.0, 45.0, 49.0, 53.0, 57.0, 61.0, and 65.0 C)