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As the administration of COX-2 inhibitors also led to reduced opioid-doses and a faster recovery of patients [66, 67], the definitive course of action (either opioid-sparing effect or anti-inflammatory effect) remains to be determined

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Iron chelators can reduce BACE1 and -secretase activity, inhibiting A production (Mandel et al., 2008)

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Necroptosis is a key pathogenic event in human and experimental murine models of non-alcoholic steatohepatitis