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Changes in circulation or shifts in body composition during significant weight reduction could potentially contribute to cramping, although this remains an area requiring further research

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The ORR of cyclophosphamide was higher when it was combined with corticosteroids (48.1%, 52 patients) and in second-line treatment (58.2%, 21 patients) than it was as monotherapy (30.6%, 15 patients), and in first-line treatment (44.3%, 17 patients)

Approximately 80% of people with MS experience fatigue, with 50% to 60% considering it their most disabling symptom

PMID: 23873438 Dhonukshe-Rutten RA et al

"Tamoxifen Use During Pregnancy"