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The antibody also reshaped the TME: M2-polarized TAMs decreased by 35%, whereas intratumoral CD8 T-cell density increased 1.8-fold, indicating ancillary immunomodulatory effects

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Frozen single-use aliquots at minus 20C can extend usability to around 90 to 120 days, though potency still drops slightly each week

The absence of a standard regimen does not mean the decision is flexible or casual

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The actions came during a highly anticipated two-day meeting that began Thursday to consider whether current Biden-era restrictions on production of seven different peptides none of which are approved drugs should be lifted