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Certain probiotic strains direct mucosal immune activity by inducing the secretion of key cytokines and B-cell growthpromoting factors, including interleukin-4 (IL-4), interleukin-5 (IL-5), and interleukin-13 (IL-13) (215, 244)

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This effect occurs primarily through inhibition of suppressor of cytokine signaling 3 (SOCS3) and activation of the janus kinase 2 (JAK2)/signal transducers and activators of transcription (STAT3) pathway (93)

Mol Endocrinol (2014) 28:122138

Protein purification XPO1 (also known as CRM1) was purified as described 109 with a minor modification: 4 L of LB medium were used instead of 6 L

doi: 10.1016/j.fsi.2018.06.031 168 RibasL.PiferrerF