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The liver, which houses the highest glutathione concentrations and performs extensive detoxification work during sleep, may benefit from elevated glutathione availability during these nighttime processes

449,450 The main lesions in glaucoma increased intraocular pressure, vascular ischemia, and hypoxia in the optic nerve head

In Pgam5 -deleted mice, it counterproductively promoted mitochondrial fusion, leading to intracellular ROS accumulation as well as oxidative stress, thus accelerating RPE cell senescence, in which the IRF/IFN- pathway was also observed, which may be related to cell senescence

In addition to transnitrosation, a slower reaction between an S-nitrosothiol and a thiol has been reported that results in the formation of glutathione disulfide (GSSG) and lower oxides of nitrogen (nitrous oxide, ammonia, hydroxylamine as well as sulfinamides) [9,30,31]

Confocal images were acquired with 405 nm laser/418495 nm filter and 488 nm laser/499615 nm filter