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doi: 10.1016/j.cellin.2025.100257 91 MengDZhuCJiaRLiZWangWSongS

Yes, some individuals experience mild abdominal cramping, bloating, or discomfort when taking vitamin B12 supplements, particularly on an empty stomach or with higher-dose formulations

2016;33:S13-21

showed that Hp KO mice experienced greater oxidative damage and renal tubular injury compared to wild-type mice when challenged with hemolysis-inducing agents ( In addition to the scarcity of human studies testing Hx replenishment as a therapeutic in SCD, another foreseeable limitation of this strategy is the cost