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The position of GSH in the model is supported by data showing that mutation of two of the arginines, R73 and R74, results in complete loss of substrate saturation with GSH (with CDNB as the electrophilic second substrate)

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216218 We have demonstrated a peptide cyclisation strategy utilising intramolecular oxime ligation between an alkoxyamine amino acid and an N-terminal -ketoamide (Scheme 9A)

For the autophagy flux index measured with BafA1, the autophagy flux index was calculated as the ratio of the LC3-II expression level in the presence of BafA1 to the LC3-II expression level in the absence of BafA1

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