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* Correspondence: Gianna Dipalma [email protected] Francesco Inchingolo [email protected] These authors have contributed equally to this work and share first authorship These authors have contributed equally to this work and share last authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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The current landscape of understanding, primarily based on limited clinical data and anecdotal experiences, calls for a more comprehensive and systematic approach to safety evaluation

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