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Despite the objective improvements, only 26.7% (Group A) and 14.3% (Group B) rated results "good" or "excellent." This highlights the gap between measurable hair count increases and subjective satisfaction patients often need to see dramatic visual change to feel satisfied, which may require longer treatment or combination approaches

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Specifically, berberine has been shown to mitigate liver injury induced by methotrexate, HFD, and CCl 4 through the activation of the Nrf2 pathway in rats [60,63,64]

A.Senz-NarcisoB.Naranjo-GalindoF

This accumulation of iA results in deleterious effects including synaptic abnormalities 6 , long-term potentiation impairment 7,8,9 and cognitive decline 8,10,11,12,13,14,15,16,17

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