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evaluated stress levels in patients with PG using the Perceived Stress Scale (PSS) and found significantly higher stress scores in patients with PG vs controls.20 Zhang et al

Yet another small molecule that has been studied extensively as a highly potent small molecule inhibitor of both human and murine CD38 is 78c, which has been shown to be 10-fold less potent against the cyclase activity than the hydrolase activity of recombinant human CD38 139

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In a previous study, most patients in a TAO cohort had mild TAO, whereas 5%6% of patients had moderate to severe TAO (336)