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however, only a few studies have characterized the glutathione gene expression profiles 19,40

Ferroptosis (iron-dependent lipid peroxidation) is also implicated as a mechanistic bridge by emerging evidence: GPX4 dysfunction and iron accumulation increase lipid peroxides, which sensitize neurons to ferroptotic death and provide extra DAMP-like signals that increase inflammasome activation [58, 59]

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Weight loss trajectory was still accelerating Phase 1 (oral): 10.4-13.1% weight loss at 12 weeks depending on dosing regimen vs 1.2% placebo Phase 2 (T2D): SC amycretin showed up to 14.5% weight loss and HbA1c reductions up to 1.8% at 36 weeks

doi: 10.1161/ATVBAHA.117.310605