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doi: 10.3389/fphar.2024.1448505 Received 13 June 2024 Accepted 30 September 2024 Published 14 October 2024 Volume 15 - 2024 Edited by Antonio Marcus de Andrade Paes, Federal University of Maranho, Brazil Reviewed by Aziz Eftekhari, Ege University, Trkiye Lin Han, DanaFarber Cancer Institute, United States Cuncai Guo, Washington University in St

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Ferroptosis is a unique, non-programmed mode of cell death characterized by the accumulation of iron, lipid hydrogen peroxide and their metabolites in the cytoplasm and by the peroxidation of polyunsaturated fatty acids (PUFAs) in the plasma membrane

It has been shown that upon homing to the tumor bed CD8 T cells accumulate lipids via CD36-mediated lipid uptake, which lowers antitumor properties and makes them prone to ferroptosis