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In aged Wistar rats with documented age-related melatonin decline: Epitalon treatment restores AANAT mRNA and enzyme activity toward young-animal levels Nocturnal melatonin amplitude is increased (RIA/ELISA measurement in plasma and pineal tissue) Circadian locomotor rhythm amplitude is partially restored in aged rodent models (wheel running actograms) Core clock gene expression (BMAL1, CLOCK, PER1/2, CRY1/2) shows partial restoration in Epitalon-treated aged tissues GHK-Cu has no documented pineal or circadian mechanism

doi: 10.1007/s11914-020-00591-6

Efficacy and safety of riluzole for treating motor function in rare dyskinesia syndromes: a systematic review with meta-analysis

Biomed J 37(3):99105

Poster Session II - ACUTE ISCHEMIC STROKE MANAGEMENT 01.00 - ACUTE ISCHEMIC STROKE MANAGEMENT - 01.04 - THROMBOLYSIS P622 - ESOC25-554 A MULTICENTER, PROSPECTIVE, RANDOMIZED, OPEN-LABEL, BLINDED-ENDPOINT TRIAL OF TENECTEPLASE FOR ACUTE NON-LARGE VESSEL OCCLUSION IN EXTENDED TIME WINDOW (OPTION): RATIONALE AND DESIGN Ran Mo 1 , Gaoting MA 1 , Junwei Hao 1 1 Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China Background and Aims: Intravenous thrombolysis, the standard of care for acute ischemic stroke (AIS) within 4.5 hours of symptom onset, is generally not offered to patients presenting beyond this time window

Copper Peptide Ghk-Cu thickens skin, improves elasticity, and increases subcutaneous fat layer 5