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In a study in 199 people monitored for five years following a kidney stone episode, subjects who increased their fluid intake enough to maintain a urine volume of 2 L or more per day had less than half the risk of recurrence compared with those who did not (Borghi 1996)

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Furthermore, the heterogenous nature of ME/CFS associated with ME/CFS subtypes, severity, and duration, in addition to inconsistencies in cytokine methodologies and repeatability suggests that cytokine profiling as a quantitative diagnostic biomarker harbours a lot of limitations and may not ultimately be feasible