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Semaglutide acts on the hypothalamus, the GI tract, and the pancreas simultaneously, producing appetite suppression, gastric emptying delay, and improved insulin secretion as three reinforcing mechanisms

This can lead to side effects such as extreme fatigue, hunger pangs, and lightheadedness

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Therapeutic dosing uses higher doses to treat existing neuropathy or deficiency

A B12 deficiency can be difficult to diagnose and is commonly confused with a folate deficiency