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The amounts of GSH and protein thiol increase significantly and the mRNA levels of gamma-glutamylcysteine synthetase and metallothionein are significantly higher in UDCA-treated hepatocytes than in controls [77]

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A causal relationship is suggested by experiments with fecal microbiota transplantation (FMT)

However, the therapeutic use of cisplatin is limited by its irreversible side effects, including transcription inhibition, cell cycle arrest, generation of reactive oxygen species (ROS), and apoptosis [3]