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After the blood flow returns, you may feel tingling and throbbing in the affected areas

Curr Protoc Mol Biol 37:1.8.1-8.10

Human Gut Microbiome: Function Matters

Specifically, alkylation of a C3-amino-quinoline derived precursor, such ascompound8, may be achieved via reductive amination with, for example, triethyl orthoformate in TFA followed by treatment with NaBH 4 to give the corresponding secondary C3-amine derivative (such as N-methyl-C3-amino-quinoline 9)