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However, these thiol reagents are known to react with cysteine 93 of Hb, leading to changes in the oxygen affinity as well as oxidative stability of the protein [4,34]

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Escher BI, Neale PA, Leusch FD (2021) Bioanalytical tools in water quality assessment

Parag Mallick, chief scientist at Nautilus Biotechnology, says he thinks the field is understanding now more than ever that tau is not a single protein that goes up and down. For example, in a single-molecule study that Mallick and his team posted to bioRxiv, researchers identified at least 130 different tau proteoforms in brain organoids and donor tissue