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The persistent accumulation of ROSarising from endogenous sources (e.g., mitochondrial leakage, enzymatic reactions) and exogenous insults (e.g., ultraviolet radiation, pollutants, tobacco)can overwhelm the antioxidant defense threshold, triggering widespread oxidative damage targeting proteins, lipids, and nucleic acids

(2014) 9:e100627

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Administration Frequency: 2-3 daily subcutaneous injections of 100mcg each

42 , 43 The content of amino acids modified by glycoxidation reactions was expressed in AFU/mg of total protein

A 10% KOH (w/v) digestion solution was added to each vial (Zhang et al., 2019)