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Abnormal microglial function was also identified in mice treated with TIOO (36)

Rang and Dales Pharmacology

FIGURE 3 3.1 Inducing Factors of Ferroptosis 3.1.1 Iron (Fe 2+ ) Metabolism As an indispensable cofactor in many enzyme metabolism processes and a catalyst of redox-cycling reaction (Stoyanovsky et al., 2019), iron is involved in a variety of important physiological and biochemical processes in vivo

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This design enables self-assembled nanomaterials to be transiently internalized into engineered bacterial cells and subsequently expelled in response to intracellular cues, thereby restoring redox and metabolic homeostasis (Fig