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NIDDK also warns that rapid weight loss and very low-calorie diets can raise the risk of gallstones

However, the lack of extensive human clinical trials means long-term safety data in humans remains limited

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This darkening happens when excess melanin, the brown pigment responsible for normal skin color, builds up in the skin

Injectable protocols may allow longer continuous use due to more predictable blood levels, while oral protocols might benefit from periodic breaks to maintain absorption efficiency

Early recognition of these warning signs is crucial, as prolonged deficiency can result in nerve damage, reduced mobility, and poor sleep quality