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Also, itaconate is increasingly produced by macrophages with a disrupted TCA cycle - as shown upon LPS stimulation (Strelko et al., 2011) - but triggers subsequently protective effects, e.g., by the inhibition of succinate dehydrogenase (which controls levels of pro-inflammatory succinate), glycolysis and pro-inflammatory NLRP3 inflammasome activation (Strelko et al., 2011), whereas activating the anti-inflammatory transcription factors NRF2 and ATF3 (Peace and ONeill, 2022)

The water matrix may contain constituents such as TOC, TSS, and TDS at levels that may require pretreatment because they could interfere with and reduce the effectiveness of the PFAS treatment technologies

7c), and metal ion binding was the GO-enrichment pathway containing the largest number of proteins (Fig

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These molecular subtypes not only highlight the heterogeneity of GBM but also provide potential targets for precision medicine