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In vivo, this cascade-regulated metabolic inhibition produced potent tumor suppression with minimal systemic toxicity, underscoring the advantage of integrating photothermal control with multi-level metabolic targeting

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Certain stress pathways including endoplasmic reticulum stress and the integrated stress response inhibit cap-dependent translation through inhibitory phosphorylation of the initiation factor eIF2

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These results suggest that STN-DBS acts on the PD circuit by specifically downregulating SCAN hyperconnectivity