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Cyclic voltammetry shows that the Cys-FeS clusters are redox-active, albeit their reduction potentials are higher than most modern ferredoxins, and closer to the range of high-potential ironsulfur proteins 30

34 , e278 (2019)

doi: 10.1111/j.1600-065X.2008.00678.x

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Schwalfenberg, 2021), sex, low intracellular GSH, cigarette smoking and presence of chronic diseases, among other factors, and GSH deficiency caused by any or all these factors may contribute to severe COVID-19 disease pathogenesis (Polonikov, 2020

Figure 1 2.1 Dysregulated iron metabolism drives ferroptosis in periodontitis Iron is an essential trace element for cellular physiological activities, and its homeostasis is tightly regulated by a complex network encompassing iron uptake, storage, release, and efflux