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Ethical considerations also arise when preventive strategies are applied broadly to asymptomatic individuals without robust predictive tools, as some may never develop dementia despite the presence of risk factors or biomarkers

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Asthenic and atrophic changes are accumulating with aging 133 , thus reducing neuroprotection and lowering brain resilience and therefore increasing the susceptibility to age-dependent neurodegenerative disorders

World J Biol Psychiatry 18(3):162214 Tseilikman VE et al (2024) Resveratrol: a multifaceted guardian against anxiety and stress disordersan overview of experimental evidence

lethal molecules were compared in a ten-point, two-fold dilution series modulatory profiling assay (high dose of dilution series in brackets): erastin (20 M), RSL3 (5 M), hydrogen peroxide (H 2 O 2 , 5 mM), artesunate (200 M), phenylarsine oxide (PAO, 1 M), taxol (0.5 M), suberoylanilide hydroxamic acid (SAHA, 50 M), trichostatin A (2.5 M), doxorubicin (2 M), fenretinide (50 M), staurosporine (STS, 0.5 M), brefeldin A (10 M), -lapachone (25 M), bortezomib (5 M), carbonyl cyanide m-chlorophenyl hydrazine (CCCP, 50 M), 2-methoxyestradio ShRNA screening and follow-up studies identified 51 initial candidate suppressor genes, each represented by 2 hairpins common to both cell lines