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Cancer Res 81:552566 Romera C, Hurtado O, Botella SH, Lizasoain I, Cardenas A, Fernandez-Tome P, Leza JC, Lorenzo P, Moro MA (2004) In vitro ischemic tolerance involves upregulation of glutamate transport partly mediated by the TACE/ADAM17-tumor necrosis factor-alpha pathway

Despite this physical separation, gut microbiota can deeply modulate epithelial cells and the immune system ( de novo synthesized metabolites such as short-chain fatty acids (SCFAs)

To prevent immune failure and cell death, signals that maintain homeostasis and promote cell survival, such as proliferation, differentiation, and maturity, are simultaneously activated

Interferon-gamma inhibits melanogenesis and induces apoptosis in melanocytes: a pivotal role of CD8 + cytotoxic T lymphocytes in vitiligo