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In summary, beneficial Clostridium and their metabolites exert multifaceted protective effects in eight major ADs by regulating gut-immune crosstalk, reinforcing intestinal barrier integrity, and alleviating disease-specific pathological damage, holding great promise as a complementary strategy for clinical immunotherapy

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This concept was tested and supported by the findings of a study that utilised photodynamic energy to thrombose and subsequently blocked the main arteries and draining veins of a mouse ear tumour [103]

Rather than replacing tissue through surgery, implants, or stem cells, it targets the functional state of existing chondrocytes, modulating age-related programs that drive degeneration