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This therapy notably elicited a strong immunological response, demonstrated by extensive infiltration of CD 8 T cells in both primary and distant tumors, thus inhibiting the advancement of metastatic lesions [41]

The purified enzyme was shown to be active with seven nephrotoxic cysteine S -conjugates derived from halogenated alkenes (Kraus et al., 2000)

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Importantly, the loss of -ketoglutaratedependent lysine demethylase activity, namely of KDM4B, has recently been linked to a suppression of DNA repair by disrupting local chromatin signaling (30, 31)

10.1016/j.toxlet.2020.01.020 [DOI] [PubMed] [Google Scholar] Kucukgoncu S., Zhou E., Lucas K

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