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J Neuroinflammation 18(1):55 Paz AA, Gonzlez-Candia A (2023) Potential pharmacological target of tight junctions to improve the BBB permeability in neonatal hypoxic-ischemic encephalopathy diseases

These molecules are loaded with nonpolar amino acids like Leucine (Leu), Valine (Val), and Isoleucine (Ile)

5F), suggesting the potential involvement of NRF2-independent pathways

Funding This work was supported by National Key R&D Program of China (2019YFA0906100 and 2021YFC3300101), National Natural Science Foundation of China (82071772), Guangdong Basic and Applied Basic Research Foundation (2022A1515010070), Shenzhen Basic Science Research Project (JCYJ20220818102018038, JCYJ20220531095612029, JSGGZD20220822100005011), Shenzhen Medical Research Fund (A2301047), and Futian Healthcare Research Project (FTWS2023066)

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Furthermore, inflammation in the gut has been linked to an increase in circulating pro-inflammatory cytokines, which are known to contribute to kidney damage and fibrosis (Lau et al., 2015)