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Placebo-controlled crossover study with dipyridamole for restless legs syndrome

Detailed protocols for the skeleton validation campaign are described in Supplementary Methods 2.2.4, with an overview in (Supplementary Fig

doi: 10.1111/jfbc.13543 58 HeydarpourFHematiNHadiAMoradiSMohammadiEFarzaeiMH

butyricum and its metabolites inducing superoxide stress and intracellular lipid accumulation, thereby enhancing tumor cell susceptibility to ferroptosis (186)

Considering that energy metabolism is also able to regulate ROS levels, we supplemented sodium pyruvate (the sodium salt form of pyruvate, a key energy substrate for cellular metabolism) or JX06 (a compound that modulates pyruvate flux into the tricarboxylic acid cycle) in GGCT-knockdown cells, respectively

This result suggests that neutrophils preferably rely on upregulation of oxPPP, rather than other pathways that can also contribute to NADPH production at baseline, to fulfil the large and rapid increase in NADPH demand associated with oxidative burst