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The primary mechanism of AOD-9604 in laboratory research models is selective beta-3 adrenergic receptor (beta-3 AR) activation

Kolodziejczyk, A

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Development was discontinued because the Phase IIb trial of 536 subjects over 24 weeks failed to meet its primary efficacy endpoint

However, retatrutide has not received approval from the MHRA or the EMA and remains an investigational agent undergoing Phase 3 trials

however, over the remaining 4 years the volume of patients remained stable