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In some cases, more aggressive treatment protocols are recommended

Basic Research in Cardiology 99 , 7682, doi:10.1007/s00395-004-0460-0 (2004)

extrapolation to human physiological outcomes has not been established through controlled human trials

Durrenberger PF, Fernando FS, Magliozzi R et al (2012) Selection of novel reference genes for use in the human central nervous system: a BrainNet Europe Study