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Starting it too late significantly reduces effectiveness

Dillon, B

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The results of further research speculated that the peptide may have boosted the ratio of Bcl-2/Bax and maybe lowered the amounts of cleaved caspase-3 and PARP, two indicators of cell death

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and (ii) delivery-related issues, as PLGA nanoparticles require further engineering to achieve high selectivity and specificity, overcome BBB restrictions, and effectively target pathological sites, and/or multi-targeting strategies may be necessary as AD exhibits multiple pathological targets (Lu et al., 2023)