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Macrophage polarization from M1 to M2 Macrophages exist on a spectrum

Commercially available CD38 mAbs for MM treatment include daratumumab (fully human, approved by FDA in 2015 and by EMA in 2016) and isatuximab (fully human, approved in 2021)

The reality is that enforcement has not been uniform

And a 2025 systematic review specifically examined BPC-157 from an orthopedic sports medicine perspective, noting the peptide's potential for promoting healing in musculoskeletal injuries including fractures, tendon ruptures, and muscle injuries in preclinical models

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