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Keeping a detailed log of progress and side effects aids in tracking the efficacy of the therapy

484,485 UPS dysregulation in SLE: autoantibodies, antigen processing, and immune signaling In SLE, aberrant UPS activity contributes to inflammatory pathways, defective antigen presentation, and impaired apoptotic processes

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doi:10.1007/s12263-014-0435-1 [28] Davis SR, Stacpoole PW, Williamson J, et al

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The Dug2-Dug3 complex is encoded by two different proteins, Dug2p and Dug3p which combine to make a functional protein complex