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Because activation of mTOR inhibits autophagy, which is essential for the removal of unneeded or damaged proteins and organelles, there is evidence that amino acids may contribute to cognitive decline and synaptic dysfunction at least in part via activation of mTOR (Meijer et al., 2015

For injectable routes, beyond localized reactions like pain or swelling at the injection site, observing for systemic effects becomes paramount

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Recommendations for the development and validation of neutralizing antibody assays in support of biosimilar assessment

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