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The study, most pronounced in short-term trials among healthy adults, focused on non-exercise interventions and showed a significant reduction in C-reactive protein but unchanged levels of IL-6 and TNF- (Gholami et al

Primary astrocytic leukodystrophies Alexander disease (AxD), the first known monogenic disease originating in astrocytes, is caused by toxic gain-of-function mutations in GFAP manifested by severe white matter damage 330,331

Curcumin also inhibited JAK2, STAT3, and Bcl-2 activation while increasing Bax and caspase-3 (Wang et al., 2022)

Mol Cell Biol 25(24):1089510906 Karunatilleke NC, Brickenden A, Choy WY (2024) Molecular basis of the interactions between the disordered Neh4 and Neh5 domains of Nrf2 and CBP/p300 in oxidative stress response

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