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For Jerne this was, as he says, 'remarkable for two reasons: they are present in serum from a normal nonimmunized animal and their number increases enormously within a week after a single injection of a phage-antigen into this animal, i.e., before the serum obtains any appreciable phage-inactivating power' (Jerne, Sept 1955)

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On the other hand, specific expansions have arisen in some species such as Aquilegia coerulea , Malus domestica , Eucalyptus grandis , and Panicum virgatum which have 58 genes

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