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Dalle-Donne I

GPx4s anti-ferroptosis role is particularly fascinatingby curbing lipid peroxidation, it prevents iron-triggered cell death, relevant in brain injuries or cancers

10.1016/j.it.2017.03.008 Trends Immunol

HUBERMAN: In order to find out the lethal dose of something, as you can imagine, unfortunately, the way these studies are done is they give animals more and more, that is higher and higher doses of a given compound, find out at what point about 50% of the population of those animals starts to die, and then that's the so-called LD50, or at least that's one crude way of describing it

[DOI] [PMC free article] [PubMed] [Google Scholar] 258.Smith SP

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