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Cui, H., Darmanin, S., Natsuisaka, M., Kondo, T., Asaka, M., Shindoh, M., Higashino, F., Hamuro, J., Okada, F., Kobayashi, M., Nakagawa, K., Koide, H., & Kobayashi, M

Graphical abstract Highlights Emerging phytotherapeutics like Aloe vera and Mahonia aquifolium showed marked inhibition of pro-inflammatory cytokines such as IL-17 and IL-23 in preclinical models

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Several studies have suggested that sphingolipid metabolism as effectors or modulators of the p53 tumor suppressor pathway, particularly sphingomyelinase and sphingosine kinase I (SK1), which are directly regulated by p53, contributing to ceramide-induced senescence in cells (Dbaibo et al., 1998

Hgl, B., Horlitz, M., Fischer, K., & Kreutz, R

[9] And while both supplement dosages were associated with higher glutathione levels at the end of the study compared to the beginning, the study lacked a control group