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According to the Montreal classification, the disease extent determined at endoscopy can be classified into three subgroups: involvement limited to the rectum (E1), involvement limited to the distal colon not exceeding the splenic flexure (E2), or involvement exceeding the splenic flexure (E3) [4]

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This age-related decline correlates with decreasing tissue regenerative capacity

GGT5 is able to degrade extracellular GSH, making the antioxidant potential of CAFs decreased

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Although, CRCs are largely inert to BRAFi monotherapy still, combined RAF and EGFR inhibition is shown to have some clinical benefit ( Resistant in vitro models commonly established from Colo205, HT-29, VACO432 and RKO cell lines and patient-derived xenografts of progression samples were shown to be sensitive to combined treatment of BRAFi and AKTi (PLX4720/vemurafenib and MK-2206) ( 2.4.2 CNS tumors We are only beginning to understand resistance mechanisms in CNS tumors (103), mainly due to the scarcity of resistance models